shockwave therapy for ED

[sammyboyfor]

https://www.peaktestosterone.com/Dox...sfunction.aspx

Doxazosin and Erectile Dysfunction
GUEST AUTHOR: Inigo

Doxazosin is an alpha-1 blocker used for hypertension. Alpha blockers work by overcoming the vasoconstricting properties of the stress neurotransmitter noradrenaline (norepinephrine). Essentially noradrenaline is the braking system to keep your erections and other "systems of relaxation" from going on forever. Unfortunately, in some men under stress and a Western lifestyle, the brakes can be on virtually all the time and this can negatively impact sexual function. Doxazosin is also prescribed for BPH (enlarged prostate) and works in a similar way on the prostate by relaxing smooth muscle tissue.

NOTE: Terazosin is another similar alpha-1 blocker that has a similar profile, i.e. is used to treat hypertension and BPH. It does not, however, have any erectile dysfunction studies under its belt yet.

Many experts feel that alpha blockers are understudied and underutilized tool in the arsenal against erectile dysfunction, because they can work miraculously for so many men. We give coverage to one other alpha blocker, which works on both the alpha-1 and alpha-2 receptors, and holds a great deal of promise for some men. See my link on Erectile Dysfunction and Phentolamine for more information. However, this medication is not yet approved in most countries as we will discuss below.

CAUTION: All the alpha blockers should only be used under a doctor's supervision, because they 1) interact very negatively with certain medications, 2) can have very serious side effects and 3) can cause priapism, an erection that does not go away and can damage the penis permanently. See my link on Common Causes of Priapism for more information on the latter. If you ever have an erection that will no go away after an hour or two, go to the E.R. immediately.

There are many reports that this blood-pressure lowering drug (an alpha-blocker) enhances the effects of PDE5i. So, though I generally have healthy blood-pressure, I persuaded my doctor, in 2008, to prescribe me daily 2mg doxazosin. (The maximum advised doxazosin dose is 16mg.) It acts as a vasodilator, and so the theoretical erection-enhancing effect is obvious.

The International Journal of Impotence Research reported in 2002 on a trial conducted by the University Hospital Genoa which investigated the efficacy and safety of sildenafil in combination with doxazosin for the treatment of non-organic erectile dysfunction in men who did not respond to sildenafil alone. 28 patients were divided in two groups: 14 were treated with doxazosin (4 mg daily) and sildenafil (100 mg before sex); the other 14 patients received sildenafil and placebo. Of the 14 patients treated with doxazosin and sildenafil, 11 showed an average increase in IIEF-EF score from 12 at baseline to 22 after 60 days. (That s much more of an increase than is generally provided by the LI-ESWT. And I don t believe it.) Only one patient in the placebo group recorded a significant increase. Blood pressure did not show significant alterations.


A Korean trial concluded in 2012 that we believe that the combination of a PDE5 inhibitor with doxazosin could be a pharmacologic strategy for simultaneously treating ED and its comorbidities and increasing response rates to PDE5 inhibitors .

Pfizer states caution is advised when PDE5 inhibitors are co-administered with alpha-blockers as the hypotensive effects of alpha-blockers and PDE5i can combine. They advise that patients already taking PDE5i, should initiate alpha-blocker therapy at the lowest dose ; and if already on alpha-blockers initiate Viagra at the lowest dose. The Levitra package leaflet offers the same advice. The Cialis package leaflet advises that you tell your doctor if you take alpha blockers.

I have checked my blood pressure when first on this combination of drugs, and it was around its usual 120/80.

Doxazosin initially, in 2008, made me feel a bit odd, slightly dizzy, but this effect disappeared after a few weeks. My doctor, without referring to PDE5i, suggested I start on half a tablet, to avoid the worst of these side effects, before taking the whole 2mg. I did that, and I thought did detect a positive effect on erections. After a couple of years I reduced the dose to 1mg a day, and then stopped altogether. Between June 2012 and January 2013 I had no doxazosin. I can t recall why I stopped doxazosin, I think I started to take the benefit for granted, and I then I just forgot about it. (And my blood pressure rose slightly around 125/85.)

Reflecting on doxazosin in early January 2013 I recalled the reliability of my erections reduced with the reduced doxazosin intake, so I restarted daily 2mg doxazosin on 20th January 2013. After a few months of noticing no improvement I reduced the dose to 1mg a day.

A private prescription allows you to buy a month s supply of 2mg Doxazosin for 1; much less than the 7.65 NHS charge.

NOTE: The most common side effect is probably dizzines. Other hypoglycemic-like symptoms can occur as well.

[afterburn]

Originally Posted by sammyboyfor

I don't like taking drugs. There is always a question mark as to what they will do to your body over the long term.

I embarked upon this exercise as a form of investigative journalism to find out whether all these alternative treatments make any difference. Before that I have never used any ED pills. Everything still works so I'm happy as I am and count my blessings.

Mind sharing what dosage mg of V and C that you tried? Since you mentioned C effect lasts 3 days, that's interesting.

While true that no one knows for sure the long term effects of ED drugs, I feel in most cases, people only need them from 40s or 50s onwards, and ED drugs have been around for 30 years with no big hoo-hah. That makes it ok to use till 70 to 80 years old, probably lose interest in bonking by then

[sammyboyfor]

Originally Posted by afterburn

Mind sharing what dosage mg of V and C that you tried? Since you mentioned C effect lasts 3 days, that's interesting.

While true that no one knows for sure the long term effects of ED drugs, I feel in most cases, people only need them from 40s or 50s onwards, and ED drugs have been around for 30 years with no big hoo-hah. That makes it ok to use till 70 to 80 years old, probably lose interest in bonking by then

Can't remember but I think it was the minimum dose for both ie quarter tablet for Viagra which is 25mg.

For Cialis I tried 5mg and it worked fantastically well.

[afterburn]

Originally Posted by sammyboyfor

Can't remember but I think it was the minimum dose for both ie quarter tablet for Viagra which is 25mg.

For Cialis I tried 5mg and it worked fantastically well.

Wow looks like C is a better option. But I suppose the price commensurates? My impression is that most clinics prescribe V which is more common?

Personally I find that some cases of "ED" also could be due to unrealistic expectations. Like some people may be only getting it from their wife or GF once weekly or even (goodness!) monthly. Then when visiting commercial sex provider, expect to do multiple shots in one session, or even bonk on several days consecutively - then when unable, think it is ED

It is like jogging 5km routinely then expect to run a marathon! And thinking something is wrong with your legs.